SAB Biotherapeutics Progressing on Therapeutic for COVID-19

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PUBLICATIONS

Publications

2018
Thomas Luke, Richard S Bennett, Dawn M Gerhardt, Tracey Burdette, Elena Postnikova, Steven Mazur, Anna N Honko, Nicholas Oberlander, Russell Byrum, Dan Ragland, Marisa St. Claire, Krisztina B Janosko, Gale Smith, Gregory Glenn, Jay Hooper, John Dye, Subhamoy Pal, Kimberly A Bishop-Lilly, Theron Hamilton, Kenneth Frey, Laura Bollinger, Jiro Wada, Hua Wu, Jin-an Jiao, Gene G Olinger, Bronwyn Gunn, Galit Alter, Surender Khurana, Lisa E Hensley, Eddie Sullivan, Peter B Jahrling; Fully Human Immunoglobulin G From Transchromosomic Bovines Treats Nonhuman Primates Infected With Ebola Virus Makona Isolate, The Journal of Infectious Diseases, jiy377, https://doi.org/10.1093/infdis/jiy377

John H Beigel, MD John H Beigel, Jocelyn Voell, RN, Parag Kumar, PharmD, Kanakatte Raviprakash, PhD, Hua Wu, PhD, Jin-An Jiao, PhD, Eddie Sullivan, PhD, Thomas Luke, MD, Richard T Davey Jr, MD; Safety and tolerability of a novel, polyclonal human anti-MERS coronavirus antibody produced from transchromosomic cattle: a phase 1 randomised, double-blind, single-dose-escalation study, The Lancet Infectious Diseases, 2018/01/11, http://dx.doi.org/10.1016/S1473-3099(18)30002-1

Jared N Silver, Cameron D Ashbaugh, Jacob J Miles, Hua Wu, Gregory T Marecki, Joyce K Hwang, Jin-An Jiao, Mark Abrams, Eddie J Sullivan, Duane R Wesemann; Deployment of Transchromosomal Bovine for Personalized Antimicrobial Therapy, Clinical Infectious Diseases, cix977, https://doi.org/10.1093/cid/cix977

2017
Derek R. Stein, Joseph W. Golden, Bryan D. Griffin, Bryce M. Warner, Charlene Ranadheera, Leanne Scharikow, Angela Sloan, Kathy L. Frost, Darwyn Kobasa, Stephanie A. Booth, Matthew Josleyn, John Ballantyne, Eddie Sullivan, Jin-an Jiao, Hua Wu, Zhongde Wang, Jay W. Hooper, David Safronetz, Human polyclonal antibodies produced in transchromosomal cattle prevent lethal Zika virus infection and testicular atrophy in mice, In Antiviral Research, Volume 146, 2017, Pages 164-173, ISSN 0166-3542, https://doi.org/10.1016/j.antiviral.2017.09.005.

Gardner, Christina L., Sun, Chengqun, Luke, Thomas, Raviprakash, Kanakatte, Wu, Hua, Jiao, Jin-an, Sullivan, Eddie, Reed, Douglas S., Ryman, Kate D., Klimstra, William B., Antibody preparations from human transchromosomic cows exhibit prophylactic and therapeutic efficacy versus Venezuelan equine encephalitis virus, 2017/05/03, Journal of Virology, 10.1128/JVI.00226-17, http://jvi.asm.org/content/early/2017/04/27/JVI.00226-17.abstract

2016
Dye, John M., Wu, Hua, Hooper, Jay W., Khurana, Surender, Kuehne, Ana I., Coyle, Elizabeth M., Ortiz, Ramon A., Fuentes, Sandra, Herbert, Andrew S., Golding, Hana, Bakken, Russell A., Brannan, Jennifer M., Kwilas, Steve A., Sullivan, Eddie J., Luke, Thomas C., Smith, Gale, Glenn, Gregory, Li, Wenfang, Ye, Ling, Yang, Chinglai, Compans, Richard W., Tripp, Ralph A., Jiao, Jin-an. Production of Potent Fully Human Polyclonal Antibodies against Ebola Zaire Virus in Transchromosomal Cattle, Scientific Reports, 2016/04/25/online Volume 6, 24897 http://dx.doi.org/10.1038/srep24897 10.1038/srep24897

Thomas Luke, Hua Wu, Jincun Zhao, Rudragouda Channappanavar, Christopher M. Coleman, Jin-An Jiao, Hiroaki Matsushita, Ye Liu, Elena N. Postnikova, Britini L. Ork, Gregory Glenn, David Flyer, Gabriel Defang, Kanakatte Raviprakash, Tadeusz Kochel, Jonathan Wang, Wensheng Nie, Gale Smith, Lisa E. Hensley, Gene G. Olinger, Jens H. Kuhn, Michael R. Holbrook, Reed F. Johnson, Stanley Perlman, Eddie Sullivan, Matthew B. Frieman. Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo. Science Translational Medicine, 2016; 8 (326): 326ra21 DOI: 10.1126/scitranslmed.3010082

2015
Matsushita H, Sano A, Wu H, Wang Z, Jiao J-a, Kasinathan P, et al. (2015) Species-Specific Chromosome Engineering Greatly Improves Fully Human Polyclonal Antibody Production Profile in Cattle. PLoS ONE 10(6): e0130699. https://doi.org/10.1371/journal.pone.0130699

2014
J. W. Hooper, R. L. Brocato, S. A. Kwilas, C. D. Hammerbeck, M. D. Josleyn, M. Royals, J. Ballantyne, H. Wu, J.-a. Jiao, H. Matsushita, E. J. Sullivan. DNA vaccine-derived human IgG produced in transchromosomal bovines protect in lethal models of hantavirus pulmonary syndrome. Science Translational Medicine, 2014; 6 (264): 264ra162 DOI: 10.1126/scitranslmed.3010082

Matsushita H, Sano A, Wu H, Jiao JA, Kasinathan P, Sullivan EJ, Wang Z, Kuroiwa Y (2014) Triple Immunoglobulin Gene Knockout Transchromosomic Cattle: Bovine Lambda Cluster Deletion and Its Effect on Fully Human Polyclonal Antibody Production. PLoS ONE, 9(3): e90383. doi:10.1371/journal.pone.0090383

2013
Sano A, Matsushita H, Wu H, Jiao JA, Kasinathan P, Sullivan EJ, Wang Z, Kuroiwa Y. (2013) Physiological Level Production of Antigen-Specific Human Immunoglobulin in Cloned Transchromosomic Cattle. PLoS ONE, 8(10): e78119. doi:10.1371/journal.pone.0078119

2009
Kuroiwa Y, Kasinathan P, Sathiyaseelan T, Jiao JA, Matsushita H, Sathiyaseelan J, Wu H, Mellquist J, Hammitt M, Koster J, Kamoda S, Tachibana K, Ishida I, Robl JM Antigen-specific human polyclonal antibodies from hyperimmunized cattle. Nat Biotechnol, 2009 Feb; 27(2):173-81. Epub 2009 Jan 18.

2008
Eddie J. Sullivan, Jerry Pommer and James M. Robl Commercialising genetically engineered animal biomedical products. Reproduction, Fertility and Development, 2008, 20, 61–66.

2006
Richt JA, Kasinathan P, Hamir AN, Castilla J, Sathiyaseelan T, Vargas F, Sathiyaseelan J, Wu H, Matsushita H, Koster J, Kato S, Ishida I, Soto C, Robl JM, Kuroiwa Y. Production of cattle lacking prion protein. Nat Biotechnol 2007 Jan;25(1):132-8. Epub 2006 Dec 31.

2004
Yoshimi Kuroiwa, Poothappillai Kasinathan, Hiroaki Matsushita, Janaki Sathiyaselan, Eddie J. Sullivan, Makoto Kakitani, Kazuma Tomizuka, Isao Ishida & James M. Robl Sequential targeting of the immunoglobulin u and prion protein genes in cattle. Nature Genetics 36, 775 – 780 (2004);Published online: 6 June 2004.

Eddie J. Sullivan, Sriranjani Kasinathan, Poothappillai Kasinathan, James M. Robl, and Philippe Collas Cloned Calves from Chromatin Remodeled In Vitro. BIOLOGY OF REPRODUCTION 70, 146–153 (2004) DOI 10.1095/biolreprod.103.021220.

2003
J.M. Robl, P. Kasinathan, E. Sullivan, Y. Kuroiwa, K. Tomizuka, I. Ishidab Artifical chromosome vectors and expression of complex proteins in transgenic animals. Theriogenology. 2003 Jan 1;59(1):107-13.

2002
Y. Kuroiwa, P. Kasinathan, Y.J. Choi, R. Naeem, K. Tomizuka, E.J. Sullivan, J.G. Knott, A. Duteau, R.A. Goldsby, B.A. Osborne, I. Ishida, J.M. Robl Cloned transchromic calves producing human immunoglobulin. Nature Biotechnology 2002 Sep;20(9):889-94. Epub 2002 Aug 12.

J.G. Knott, P. Kasinathan, H. Wu, C.L. He, R.A. Fissore and J.M. Robl Porcine Sperm Factor Supports Activation and Development of Bovine Nuclear Transfer Embryos. Biology of Reproduction 2002 Apr;66(4):1095-103.

2001
P. Kasinathan, J.G. Knott, A.R. Spell and J.M. Robl A Comparison of Somatic Cell Nuclear Transfer with Fibroblasts of Different Genetic Origin. Theriogenology December 15, 2001.

P. Kasinathan, J.G. Knott, Z. Wang, D.J. Jerry and J.M. Robl Production of calves from G1 fibroblasts. Nature Biotechnology 2001 Dec;19(12):1176-8.

P. Moreira, J. Bomar, J.M. Robl and P. Collas Identification of A-Kinase Anchoring Protein AKAP95 as a Molecular Marker of Nuclear Reprogramming after Nuclear Transfer. Theriogenology

J.G. Knott, E.J. Sullivan, P. Kasinathan, C.L. He, H. Wu, J.M. Robl and R.A. Fissore The Generation of a Functional IP3R-1 Knockout in Bovine Oocytes. Theriogenology

P. Kasinathan, J.G. Knott, P.N. Moreira, A.S. Burnside, D.J. Jerry and J.M. Robl Effect of Fibroblast Donor Cell Age and Cell Cycle on Development of Bovine Nuclear Transfer Embryos In Vitro. Biology of Reproduction 2001 May;64(5):1487-93.

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