PUBLISHED RESEARCH


Thomas Luke, Hua Wu, Jincun Zhao, Rudragouda Channappanavar, Christopher M. Coleman, Jin-An Jiao, Hiroaki Matsushita, Ye Liu, Elena N. Postnikova, Britini L. Ork, Gregory Glenn, David Flyer, Gabriel Defang, Kanakatte Raviprakash, Tadeusz Kochel, Jonathan Wang, Wensheng Nie, Gale Smith, Lisa E. Hensley, Gene G. Olinger, Jens H. Kuhn, Michael R. Holbrook, Reed F. Johnson, Stanley Perlman, Eddie Sullivan, Matthew B. Frieman. 
Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo. Science Translational Medicine, 2016; 8 (326): 326ra21 DOI: 10.1126/scitranslmed.3010082

J. W. Hooper, R. L. Brocato, S. A. Kwilas, C. D. Hammerbeck, M. D. Josleyn, M. Royals, J. Ballantyne, H. Wu, J.-a. Jiao, H. Matsushita, E. J. Sullivan. DNA vaccine-derived human IgG produced in transchromosomal bovines protect in lethal models of hantavirus pulmonary syndromeScience Translational Medicine, 2014; 6 (264): 264ra162 DOI: 10.1126/scitranslmed.3010082

Matsushita H, Sano A, Wu H, Jiao JA, Kasinathan P, Sullivan EJ, Wang Z, Kuroiwa Y (2014) Triple Immunoglobulin Gene Knockout Transchromosomic Cattle: Bovine Lambda Cluster Deletion and Its Effect on Fully Human Polyclonal Antibody Production. PLoS ONE, 9(3): e90383. doi:10.1371/journal.pone.0090383

Sano A, Matsushita H, Wu H, Jiao JA, Kasinathan P, Sullivan EJ,  Wang Z, Kuroiwa Y. (2013) Physiological Level Production of Antigen-Specific Human Immunoglobulin in Cloned Transchromosomic Cattle. PLoS ONE, 8(10): e78119. doi:10.1371/journal.pone.0078119

Kuroiwa Y, Kasinathan P, Sathiyaseelan T, Jiao JA, Matsushita H, Sathiyaseelan J, Wu H, Mellquist J, Hammitt M, Koster J, Kamoda S, Tachibana K, Ishida I, Robl JM  Antigen-specific human polyclonal antibodies from hyperimmunized cattle. Nat Biotechnol, 2009 Feb;27(2):173-81. Epub 2009 Jan 18.

Eddie J. Sullivan, Jerry Pommer and James M. Robl Commercialising genetically engineered animal biomedical products. Reproduction, Fertility and Development, 2008, 20, 61–66. 



Richt JA, Kasinathan P, Hamir AN, Castilla J, Sathiyaseelan T, Vargas F, Sathiyaseelan J, Wu H, Matsushita H, Koster J, Kato S, Ishida I, Soto C, Robl JM, Kuroiwa Y. Production of cattle lacking prion protein.Nat Biotechnol 2007 Jan;25(1):132-8. Epub 2006 Dec 31.



Yoshimi Kuroiwa1, 3, Poothappillai Kasinathan2, Hiroaki Matsushita2, Janaki Sathiyaselan2, Eddie J. Sullivan2, Makoto Kakitani3, Kazuma Tomizuka3, Isao Ishida3* & James M. Robl2* Sequential targeting of the immunoglobulin u and prion protein genes in cattle. Nature Genetics  36, 775 - 780 (2004);Published online: 6 June 2004

 

Eddie J. Sullivan, Sriranjani Kasinathan, Poothappillai Kasinathan, James M. Robl, and Philippe Collas Cloned Calves from Chromatin Remodeled In Vitro. BIOLOGY OF REPRODUCTION 70, 146–153 (2004) DOI 10.1095/biolreprod.103.021220



J.M. Robl, P. Kasinathan, E. Sullivan, Y. Kuroiwa, K. Tomizuka, I. Ishidab  Artifical chromosome vectors and expression of complex proteins in transgenic animals. Theriogenology. 2003 Jan 1;59(1):107-13. 


Y. Kuroiwa, P. Kasinathan, Y.J. Choi, R. Naeem, K. Tomizuka, E.J. Sullivan, J.G. Knott, A. Duteau, R.A. Goldsby, B.A. Osborne, I. Ishida, J.M. Robl Cloned transchromic calves producing human immunoglobulin. Nature Biotechnology 2002 Sep;20(9):889-94. Epub 2002 Aug 12. 


J.G. Knott, P. Kasinathan, H. Wu, C.L. He, R.A. Fissore and J.M. Robl Porcine Sperm Factor Supports Activation and Development of Bovine Nuclear Transfer Embryos. Biology of Reproduction 2002 Apr;66(4):1095-103.



P. Kasinathan, J.G. Knott, A.R. Spell and J.M. Robl  A Comparison of Somatic Cell Nuclear Transfer with Fibroblasts of Different Genetic Origin. Theriogenology  December 15, 2001 

 

P. Kasinathan, J.G. Knott, Z. Wang, D.J. Jerry and J.M. Robl  Production of calves from G1 fibroblasts. Nature Biotechnology 2001 Dec;19(12):1176-8. 

 

P. Moreira, J. Bomar, J.M. Robl and P. Collas Identification of A-Kinase Anchoring Protein AKAP95 as a Molecular Marker of Nuclear Reprogramming after Nuclear Transfer. Theriogenology

J.G. Knott, E.J. Sullivan, P. Kasinathan, C.L. He, H. Wu, J.M. Robl and R.A. Fissore The Generation of a Functional IP3R-1 Knockout in Bovine Oocytes. Theriogenology 



P. Kasinathan, J.G. Knott, P.N. Moreira, A.S. Burnside, D.J. Jerry and J.M. Robl Effect of Fibroblast Donor Cell Age and Cell Cycle on Development of Bovine Nuclear Transfer Embryos In Vitro. Biology of Reproduction 
2001 May;64(5):1487-93.