Sioux Falls, SD, April 26, 2017 – SAB Biotherapeutics (SAB), a clinical-stage biopharmaceutical development company, today announced that Thorkil Kastberg Christensen has joined their Board of Directors. SAB, which was founded in 2014, develops human antibody therapeutics using its first-of-its-kind immunotherapy platform.
Christensen brings to SAB decades of global business strategy and execution as former Chief Financial Officer of Denmark-based Novo A/S, which invests and manages the assets of the Novo Nordisk Foundation valued at about US $40 billion. He also established Novo Nordisk organizations around the world over two decades–as CEO of China and Vice President of International Operations. > > >
Sioux Falls, SD, – SAB Biotherapeutics (SAB), a clinical-stage biopharmaceutical development company, today officially announced the hire of Christoph L. Bausch, Ph.D. as its Chief Science Officer (CSO).
Dr. Bausch joins SAB’s executive team as an experienced research scientist and business development executive who has led the successful discovery, development and commercialization of platform technologies. Former CSO, Dr. Jin-an Jiao, who helped establish SAB’s technology, has transitioned to a strategic consultant role for the company. > > >
20 SEPTEMBER 2016
SAB Biotherapeutics' Immunotherapy Proposal Among Top Platform Technology Solutions in Recent WHO Report
Platform leveraging transchromosomic cattle shows promise for global response to epidemics
Bethesda, MD and Sioux Falls, SD, – SAB Biotherapeutics (SAB), a clinical-stage biopharmaceutical development company, announced today that its DiversitAb human antibody production platform, leveraging transchromosomic cattle (Tc Bovine™), was identified as of one of the six most meritorious proposals emerging from the World Health Organization (WHO) Public consultation on platform technologies for priority infectious diseases with epidemic potential.
This consultation was part of the WHO Research & Development Blueprint, a global strategy and preparedness plan that allows the rapid activation of R&D activities that can be used to save lives and avert large-scale crisis during epidemics. SAB Biotherapeutics’ technology was the only immunotherapy platform among the six finalists (of 35 proposals), which also included three vaccine platforms, a diagnostic technology and a technology covering all product streams. > > >
Sioux Falls, S.D., – SAB Biotherapeutics, Inc. (SAB), a clinical-stage biopharmaceutical development company, announced today it has received a Small Business Innovation Research (SBIR) Grant from the National Institutes of Health (NIH) for up to $1.42 Million to advance its treatment for influenza. The funding–specifically for the production and preclinical testing of its novel antibody therapeutic targeting influenza viruses–is a research collaboration project with the University of South Dakota (USD) Sanford School of Medicine. The project was initiated through the BioSNTR, a distributed research initiative that facilitates academic and industry research collaborations to advance biotechnology and commercialize innovations. > > >
Sioux Falls, S.D., – SAB Biotherapeutics, Inc. (SAB), a clinical-stage biopharmaceutical development company, announced today that it has been awarded a contract for up to $5.3 million by the Biomedical Advanced Research and Development Authority (BARDA) within the Office of the Assistant Secretary for Preparedness and Response in the U.S. Department of Health and Human Services (HHS). The funding will be used for advanced clinical manufacturing and testing for SAB’s novel antibody therapeutic (SAB-301) to treat MERS-CoV. > > >
Sioux Falls, S.D., – SAB Biotherapeutics, Inc. (SAB), a leading biopharmaceutical development company, announced today that Phase I Clinical Trials are underway for its human antibody treatment (SAB-301) for MERS-CoV. The goal of the study–sponsored, funded and conducted by National Institutes of Health (NIH)–is to evaluate the dosage and safety of this new therapeutic. > > >
Baltimore, MD., – In a new study, University of Maryland School of Medicine researchers have had promising results with a new treatment for Middle East Respiratory Syndrome (MERS). The study, published today in the journal Science Translational Medicine, found a new treatment that protected mice from MERS infection. > > >
Sioux Falls, S.D., – SAB Biotherapeutics, Inc. (SAB), a leading biopharmaceutical development company, focused on advancing some of the most innovative molecular genetics and human antibody technology in the world, today announced the appointment of four internationally respected immunotherapy specialists to its newly formed Scientific Advisory Board. > > >
Sioux Falls, S.D.,—The Sioux Falls Development Foundation is announcing a $3 million equity investment in Sioux Falls-based SAB Biotherapeutics to help grow its unique disease-fighting platform. > > >
3 DECEMBER 2014
SAB Biotherapeutics and U.S. Army team up to treat Hantavirus
Human antibodies produced in genetically designed cows can protect against deadly diseases
Sioux Falls, S.D., – SAB Biotherapeutics, Inc. (SAB), a leading biopharmaceutical development company, has teamed up with the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) to address the potentially deadly hantavirus using a novel approach to developing protective antibodies against it. Their work, published in the November 26, 2014 online edition of Science Translational Medicine, provides proof of concept for producing antibodies against a broad range of human pathogens, including hantavirus. > > >
Fort Detrick, MD – Scientists investigating the potentially deadly hantavirus have used a novel approach to developing protective antibodies against it. Their work, published in today’s online edition of Science Translational Medicine, provides proof of concept for producing antibodies against a broad range of human pathogens. > > >
A small biomedical company has engineered a way for cows to produce large quantities of human antibodies to fight infectious disease. Although the technology won’t be available for perhaps three to five years, it could be a new method to address such infectious diseases as influenza, Ebola, Zika and Middle East respiratory syndrome (MERS).
The technology, devised by SAB Biotherapeutics, a privately held company in Sioux Falls, South Dakota, followed the same principle used in a handful of cases during the Ebola outbreak. Physicians took plasma from convalescent patients and gave it to sick patients. That worked well in a few cases, but a few patients can’t provide enough plasma to counter a widespread outbreak.
Cows might offer a solution: A cow can produce 30 to 60 liters of concentrated antibodies per month–enough to potentially treat several hundred patients. Humans, on the other hand, are not as industrious—a patient can produce only 4 liters per month, enough to treat about three people. > > >
4 OCTOBER 2016
COWS ENGINEERED WITH HUMAN GENES COULD STOP OUR NEXT DISEASE OUTBREAK
Cattle that can crank out human antibodies are being tested as a first line of defense against infectious diseases.
During the most recent Ebola outbreak in West Africa, health-care workers treated some sick patients by injecting them with plasma—the translucent part of the blood—taken from individuals who had survived the disease. In the absence of an approved drug to treat patients, the hope was that protective proteins in the donor plasma would help recipients fight the disease and recover.
A biotech company wants to use this same approach to treat a variety of infectious diseases, with one key difference: cows, not humans, will be the plasma donors. > > >
Leaders from Sioux Falls-based SAB Biotherapeutics are traveling to Saudi Arabia next week for talks with the Saudi government that might lead to a clinical trial related to the country’s outbreak of Middle East Respiratory Syndrome, or MERS. > > >
26 NOVEMBER 2014
GMO Cattle Produce Serum to Fight Hantavirus – Is Ebola Next?
NBC News, By Maggie Fox
Dr. Kent Brantly donated a gallon or more of his own blood serum to help treat other patients with Ebola. Now, researchers say they've used genetically engineered cattle to do something similar.
Serum from the cattle has been used to treat hantavirus — a rare but highly deadly virus that causes regular outbreaks, including one that killed three campers at Yosemite National Park in 2012. > > >
Humans have been using antibody therapies to treat infectious disease for more than 100 years. Blood plasma from influenza survivors administered to sick patients in 1912 may have contributed to their dramatic turnaround. In the years since, immune proteins from survivors have been administered to infected individuals in an attempt to combat diseases like Lassa fever, SARS, and even Ebola.
It’s hard, however, to find survivors who can donate plasma containing these lifesaving immune proteins. Now, a team led by researchers at the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) in Frederick, Maryland, has used genetically engineered cows to produce large amounts of human antibodies against hantavirus, an often deadly disease mainly transmitted from rodents to people. > > >
26 NOVEMBER 2014
Human Antibodies Produced in DNA-Vaccinated Cows Protect
in Lethal Models of Hantavirus
Medical Xpress, US Army Medical Research Institute of Infectious Diseases
Scientists investigating the potentially deadly hantavirus have used a novel approach to developing protective antibodies against it. Their work, published in today's online edition of Science Translational Medicine, provides proof of concept for producing antibodies against a broad range of human pathogens. > > >
SAB Biotherapeutics, Inc. Producing Human Antibodies to Combat Disease
Broader Research Community a South Dakota Advantage
While using animals to produce human antibodies may have sounded like a work of science fiction
in the not-too-distant past, that’s exactly what one South Dakota company – SAB Biotherapeutics, Inc. is currently doing. > > >
Animal Biotech industry Thrives in State's Climate
In labs throughout Sioux Falls region, scientists are working
to come up with next great discoveries to cure diseases
Sioux Falls, South Dakota – On a farm near Flandreau, miniature pigs are genetically engineered to have human diseases. In a pasture near Canton, sheep with no genetic modifications are raised for medical testing. Across the border in Iowa, cows in a stress-free environment are cloned and genetically engineered to produce human antibodies. Their job is to donate plasma a few times a month. In labs throughout the Sioux Falls region, scientists are working to come up with the next great discoveries to cure diseases and help people live better lives. > > >
SAB Biotherapeutics Brings New Technology to BIO
Sioux Falls, South Dakota – Attendees at BIO will have a glimpse of a new technology from SAB Biotherapeutics, Inc. (SAB) that can revolutionize the way diseases are treated and even prevented.
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Game-Changing Technology Nears Clinical Stage
World’s First Large Animal Platform to Produce Fully Human Antibodies
It is not often that something genuinely novel comes along to completely transform an approach,
a treatment, a complete perspective…and truly a world of possibility. It’s called a game changer.
The new technology from SAB Biotherapeutics, Inc. (SAB) is just that. > > >